Many drugs and vaccines are not tested, citing an archaic law that all they have to do is state that they are similar to an already approved drug; even if that drug or vaccine has been shown to be harmful. I strongly suggest banking your child's eggs or sperm before allowing your teen or pre-teen to receive the Gardasil HPV vaccine. Pharmaceutical companies use associative advertising to make their products look as safe as the little kitten who lives next door.
Advanced Search Abstract Objective. It was first described by Maurice Raynaud over years ago [ 1 ], and may occur as a primary phenomenon or may be secondary to other disorders, such as systemic sclerosis.
Treatment may be offered in these more severe cases, usually in the form of a vasodilator drug. Although a variety of vasodilators are available, none is universally effective and the response to treatment is often idiosyncratic. It seems likely that the most effective drugs will be those which directly target key mediators, and a search for novel agents has led to studies of angiotension receptor antagonists [ 4 ] and of the potent synthetic antioxidant probucol [ 5 ].
Both of these drugs were apparently superior to nifedipine in controlled clinical trials. An increasing body of evidence suggests that serotonin may be involved. Serotonin is a selective vasoconstrictor in vivo: Indeed, high levels of von Willebrand factor, indicating severe endothelial damage, are a poor prognostic indicator in systemic sclerosis [ 14 ].
Furthermore, adenosine nucleotides and serotonin possibly arising from platelets stimulate the release of von Willebrand factor from endothelial cells in vitro [ 15 ]. Subgroup analysis was used to identify particular subgroups of patients who were more likely to derive benefit from this alternative therapeutic agent.
Patients were randomized to receive either fluoxetine 20 mg daily or nifedipine LA 40 mg daily for 6 weeks, after which assessments were repeated. This was followed by further blood sampling and thermographic assessment. Significant cardiorespiratory and renal disease or epilepsy or any medical condition contraindicating the use of nifedipine or fluoxetine and the concurrent use of calcium channel blockers or SSRIs for other indications were also exclusion criteria.DEATH BY VACCINATION.
PART OF THE WATCHDOG USA NETWORK. If vaccines were safe, there would not be a VAERS COURT to pay out Billions of Tax Dollars to families of dead and crippled children. Atomoxetine—a norepinephrine-predominant SNRI used in the treatment of ADHD and, off-label, major depression.
Was approved by FDA in Originally considered to be a selective norepinephrine reuptake inhibitor, but research subsequently revealed that it significantly inhibits the reuptake of serotonin at clinical dosages as well.; Desvenlafaxine —the active metabolite of venlafaxine.
Selective serotonin reuptake inhibitors (SSRIs) SSRIs are the most commonly prescribed class of antidepressants. An imbalance of serotonin may play a role in depression.
QUESTION: Which characteristics of published trials might account for differences in the effect of clomipramine and selective serotonin reuptake inhibitors in obsessive-compulsive disorder?
Studies were identified using Medline, Current Contents, PsychInfo, . A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT).
This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic neurotransmission. Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a class of medications that are effective in treating depression.
SNRIs are also sometimes used to treat other conditions, such as anxiety disorders and long-term (chronic) pain, especially nerve pain.